HIV therapy

The Summer of No Shame 2013 | Facebook

Christian Ledan

My name is Christian Ledan and I live in NYC, NY.

I learned of my #HIV status through the mail, on a Saturday, alone in my apartment, in Brooklyn, in April 2002. A few months prior I had flu like symptoms that I couldn’t shake and had gone to doctor in January, again in March, both times an HIV test was done with the results coming back negative. Due to being ill, I started thinking about what would happen if I died; who would pay for medical expenses and funeral costs? You know… all those morbid thoughts that one has when they get sick. Well, I decided to get a small life insurance plan that would help cover such costs since I was single and without children. 

In March of 2002 I met with a financial advisor signed up for retirement plan/life insurance policy. Wrote a check for the deposit and scheduled the appointment for the phlebotomist to come draw blood (a requirement for the life insurance plan). April Fools’ Day of all days was the day. Twenty days later, I received correspondence from the company. In the envelope was a check equal to the amount of my deposit, a letter stating that I was denied the plan, and a copy of the blood work which appeared to indicate that I had HIV antibodies. I had to wait until that Monday to fax the results to doctor. It was confirmed two weeks later. The same week my doctor confirmed the diagnosis I was laid-off from my job. 

I am what is called a nonprogressor; at the time of my diagnosis it common to suggest to wait before starting any HIV treatment. So that is what I did; waited. My t-Cells were always high and my Viral Load low. Physically, my body was doing a great job controlling the virus. Emotionally, I was torn up inside. I hid my pain very well from friends and family. I moved to Tampa to bring on a change and things started looking up. New home and a new job wasn’t enough. Suddenly I found myself using crystal meth. This became my solution to dealing with the pain. I had done plenty of club drugs for many years back when I dancing every weekend away but this time, with crystal, it was not on the dance floor. It was in my home. 

My blood work still looked good even after moving back to NYC and progressing to a daily IV user of meth. By now my new doctor was recommending that I start HIV meds, due to the advancements in medicine and less side effects, and I continued to decline. I excuse was that I am allergic to so many things (which is true) and I feared having a deadly reaction to the medication. The truth, I read up on some of the medications and what I truly feared was overdosing because I was active user of crystal meth and other substances. Truly insane thinking!

Today, I am in recovery. I’ve been clean since 10-24-2010! In the Spring of 2011 I had a talk with my current doctor and, although my numbers are still great, with his help I made the decision to start HIV treatment. He told me it was time to give my body a break and to let the medication do the work for me. I’ve been on Truvada and Isentress since August 2011, I am undetectable and my t-Cells are high. Recovery has helped me feel comfortable in my own skin and there is no shame in being HIV+.

They created an HIV resistant cell

Researchers at Stanford University have created HIV-resistant T-cells, a breakthrough that, if proven successful in humans, could potentially stop the virus from developing into AIDS.

The discovery was announced in Tuesday’s issue of Molecular Therapy, and according to researchers, could replace lifelong drug treatments and protect the immune systems of those infected.

A Stanford press release explained the process:

A new study describes the use of a kind of molecular scissors to cut and paste a series of HIV-resistant genes into T-cells. […] By inactivating a receptor gene and inserting additional anti-HIV genes, the virus was blocked from entering the cells, thus preventing it from destroying the immune system.

HIV works by entering and ultimately killing an individual’s T-cells, leading to a collapse of the immune system. Researchers were quick to point out that the therapy is not a cure for HIV, but rather a method to make patients immune to it.

“Once [a person contracts HIV], they become susceptible to all sorts of infections and cancers, and that’s what kills the patient ultimately–not the virus,” explained the study’s principal researcher, Dr. Matthew Porteus, to The Huffington Post. “So our goal is to build an immune system that is resistant to the virus.”

In theory, Porteus and his team could replace a percentage of a patient’s T-cells with the HIV-resistant cells. As the HIV-sensitive cells would die off, the resistant cells would reproduce, eventually creating an immune system of entirely HIV-resistant cells.

“The body has an incredible way of balancing itself,” explained Porteus. “The virus would have no more cells to infect.”

Currently, doctors use drug therapy to help achieve this affect. But because the HIV virus is notorious for mutating, many patients must take dozens of pills a day for the rest of their lives. Should the gene therapy prove successful, the pills–and their sometimes unbearable side effects–would no longer be necessary.

“If you put one roadblock in front of HIV, it is very good about getting around that,” said Porteus. “What we’ve done in our study is shown that we can add multiple layers of protection, creating what is essentially a complete resistance to HIV.”

The Stanford breakthrough is one of several increasingly positive studies in the fight against HIV. In 2007, researchers in Berlin completed a stem cell transplant on an HIV-positive man that appeared to cure him of the virus. Dubbed the “Berlin Patient,” Timothy Ray Brown is still HIV-free four years later.

“The obvious question is why we don’t we do that for everyone,” said Porteus. He explained that the conditions for such a phenomenon are so rare, that a stem cell cure might not be practical on a large scale.

“But if we can create immune systems that are protected against HIV, you could reach a state where you had a fully-functioning immune system with a low level of HIV infection that wouldn’t cause any problems,” he added.

According to the San Francisco Chronicle, researchers plan to conduct more lab work before starting animal testing. The team hopes to begin testing on humans within the next five years.

Treatment News : Certain Meds Mixed With Grapefruit Juice Can Be a Fatal Cocktail

imageThe Canadian scientist who first discovered that grapefruit can alter certain prescription drug levels in the body has released an updated list of 85 medications that may cause such reactions, 43 of which can cause fatal interactions, The New York Times reports. A clinical pharmacologist at the Lawson Health Research Institute in London, Ontario, David Bailey, PhD, updated his list to reflect releases of new medications over the past four years. The list includes drugs to treat HIV, high cholesterol and cancer, as well as immunosuppressants, psychotropic medications, synthetic opioids, birth control and estrogen.

How often such reactions occur is up for debate, but Bailey stresses that however rare they may be, anyone taking prescription medication and consuming grapefruit juice or grapefruit, as well as pomelo, lime and marmalade, should consult the list of drugs and monitor for symptoms that may indicate a side effect of the combination. Timing of grapefruit consumption is not relevant; it must be avoided entirely to avoid the potential interaction.

To see the full list of medications, click here.

To read the New York Times report, click here. 

Have a HAART... (part II)

A lot happened over the weekend….

I started HIV-treatment… just 3 pills a day… I’m feeling just fine… no side effects

I also, went on a date… first date in a very very very long time.  Had a wonderful time… we did kiss… first kiss in over 2 years for me… He says that he would like to see me again… He is HIV negative; that kicked up a few things with me.  This would be first for me as well; I have only ever dated someone that is pozitve since my diagnosis 10 years ago.

Let’s see… what else… I started taking lessons in sign language… 1-on-1 for an hour on Sundays.  

I am still transitioning off of public assistance.  Starting next month, I will be paying about 90% of my rent… I can still receive Food Stamps for about a year and keep Medicaid because my employer doesn’t offer health insurance at this time.

In just 2 months, I will be 40 years old.  I am still working on my 40lbs by 40yo Challenge.  I need to lose 13 more pounds.  However, I am not sure how much fat I have actually lost.  I know that I have gained muscle and my waist size is getting smaller. So, there is a chance that I might hover around my current weight of 171lbs  if I continue to gain muscle mass and shed some fat.  Anyway, I feel great.

___________

Just wanted to give a quick update on what’s happening with me.

New hope against HIV/AIDS

A silver bullet to defeat HIV/AIDS still doesn’t exist, but the world is getting closer.

An international study released this week found that transmission of the virus can be nearly eliminated if patients are simply given drug therapy as early as possible.

The trial was among 1,763 couples where one partner was infected. The couples were split into two groups - in one group the infected partners had received anti-retroviral drugs immediately upon diagnosis, in the other, the infected partners had begun therapy later.

Over the course of six years, researchers found that those who had started treatment early were 96 percent less likely to transmit the virus to their partners than those who had begun treatment later. The data was so overwhelming that the study was terminated years ahead of schedule.

The results are the first to prove what HIV/AIDS experts already suspected - that immediate treatment offers major health benefits. They also back San Francisco public health officials’ much-debated recommendation from last year that people should be treated as soon as possible after their diagnosis.

“The pendulum has really swung towards early treatment,” said Dr. Grant Colfax, director of HIV prevention for San Francisco’s Public Health Department.

It’s poignant that the study’s release is happening just weeks before the 30th anniversary of the first reports of HIV in the United States.

“This year there have been a lot of positive signs in terms of turning the epidemic around,” Colfax said. “Maybe in another 30 years, (HIV) won’t be around.”

In the meantime, this study poses a new challenge to public health officials. The evidence is clearly starting to show that it’s much better to treat patients earlier, but from where will the money come?

Anti-retroviral medications have made huge strides in the past five years. The side effects are less debilitating and the drugs are more widely available in poor countries that have been racked by the epidemic.

Unfortunately, they’re still very expensive. Many poor countries, already struggling to deliver therapy to those with full-blown AIDS, will probably conclude that they can’t afford to launch early treatment programs for people who aren’t already sick.

That would be a mistake. Yes, anti-retroviral medications are pricey - but what are really expensive are new HIV infections. Early treatment offers enormous returns for patients’ health and productivity, and now, it appears, that benefit extends to their partners as well. It doesn’t come cheaper than that.

This article appeared on page A - 9 of the San Francisco Chronicle